Endocrine Abstracts

The local expression of bone morphogenetic protein-2 (BMP-2) during pituitary development mediates the commitment of undifferentiated cells to the gonadotroph lineage. In the current study, we have used alphaT3-1 and LbetaT2 cells, which represent different stages of gonadotroph development to examine BMP-2 receptor (BMPR) expression and effects of BMP-2 on cell signalling pathways and cell proliferation. In bone, signal transduction via BMPRs requires heteromeric complexing b...